Myocardial histomorphometry of rat in doxorubicin-induced cardiomyopathy


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DOI:

https://doi.org/10.32523/2616-7034-2026-154-1-177-191

Keywords:

doxorubicin-induced cardiomyopathy, ultrastructure, α-actinin-2, cardiac troponin T, succinate dehydrogenase, lactate dehydrogenase, parenchymal-stromal ratio

Abstract

Morphological changes in the structural components of the myocardium were established in an experimental model of cardiomyopathy induced by doxorubicin. The most informative markers of disease progression were: α-actinin-2 (ACTN2; λ = 0.0051, р = 0.005), cardiac troponin T (TNNT2; λ = 0.0085, р = 0.008), succinate dehydrogenase (SDG; λ = 0.0097, р = 0.010), lactate dehydrogenase (LDG; λ = 0.0135, р = 0.014) and parenchymal-stromal ratio (PSR; λ = 0.0137, р = 0.014).

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Published

2026-03-31

How to Cite

Fiodorova Е. ., & Mankovskaya С. . (2026). Myocardial histomorphometry of rat in doxorubicin-induced cardiomyopathy. BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series, 154(1), 177–191. https://doi.org/10.32523/2616-7034-2026-154-1-177-191

Issue

Vol. 154 No. 1 (2026)

Section

Статьи