Histomorphometric parameters of rat myocardium in doxorubicin-induced cardiomyopathy

Abstract

 Morphological changes in the structural components of
the myocardium were identified in an experimental model of doxorubi
cin-induced cardiomyopathy. The most informative markers of disease
progression were: α-actinin-2 (ACTN2; λ = 0.0051, p = 0.005), cardiac
troponin T (TNNT2; λ = 0.0085, p = 0.008), succinate dehydrogenase
(SDH; λ = 0.0097, p = 0.010), lactate dehydrogenase (LDH; λ = 0.0135, p
= 0.014), and the parenchymal-stromal ratio (PSR; λ = 0.0137, p = 0.014).
The obtained data may serve as additional criteria for the detection of
the early stage of toxic myocardial damage, as well as for the evaluation
of the efficacy of novel cardioprotective agents.