The role of copper compounds in neurological disorders due to their excessive or insufficient supply to the brain tissue


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Authors

  • A.E. Konkabaeva Ye.A.Buketov Karaganda State University
  • Sh.A. Mukhanova Ye.A.Buketov Karaganda State University
  • G.M. Tykezhanova Ye.A.Buketov Karaganda State University
  • Sh.M. Nugumanova Ye.A.Buketov Karaganda State University

Keywords:

copper, brain tissue, central nervous system, excess and deficiency of copper, neu rodegenerative disorders, Wilson’s disease

Abstract

This literature review covers the topic of nervous system disorders caused by defects in
copper metabolism in brain tissue. The role and participation of this element in many physiological
functions of the central nervous system in normal and pathological conditions are identified and
described. Neurodegenerative disorders in which there is an accumulation of "free" copper in the
brain tissue are considered (Alzheimer’s, Wilson, Menkes). Genetic diseases caused by excessive or
insufficient copper intake in the brain tissue, which manifest as neurological disorders, are described.
Particular attention is paid to the features of copper metabolism in brain tissue with neurological
disorders. This direction is also complemented by a description of pathological changes during the
deposition of copper in the nervous system. The article reveals the mechanisms of toxicological
effects in case of excessive intake of copper in the nervous tissue of experimental animals.

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Published

2026-06-07

How to Cite

Konkabaeva, A. ., Mukhanova, S. ., Tykezhanova, G. ., & Nugumanova, S. . (2026). The role of copper compounds in neurological disorders due to their excessive or insufficient supply to the brain tissue. BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series, 127(2), 43–52. Retrieved from https://bulbio.enu.kz/index.php/main/article/view/997

Issue

Vol. 127 No. 2 (2019)

Section

Статьи