The role of mitochondria and microRNAs in radiation-induced aging


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Authors

  • P.M. Toibekova L.N. Gumilyov Eurasian National University
  • O.V. Bulgakova L.N. Gumilyov Eurasian National University
  • R.I. Bersimbai L.N. Gumilyov Eurasian National University

Keywords:

ionizing radiation, cell aging, DNA damage, microRNA

Abstract

Population aging is accelerating worldwide, straining the global economy and health services. Cellular senescence is a significant contributor to various age-related neurological and neuropsychiatric disorders, including Alzheimer's disease and Parkinson's disease. Some external factors, such as exposure to ionizing radiation, can accelerate aging.

In recent years, it has become known that the post-transcriptional control system of gene expression by short single-stranded RNA molecules, called microRNAs, is of great importance in the regulation of normal physiological processes and in the pathogenesis of many diseases, including age-related diseases. This article reviews the biological effects of radiation, the effects of radiation on aging in various cell types, and the relevant molecular mechanisms of microRNAs.

Published

2023-06-29

How to Cite

Toibekova П., Bulgakova О., & Bersimbai Р. (2023). The role of mitochondria and microRNAs in radiation-induced aging. BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series, 143(2), 18–26. Retrieved from https://bulbio.enu.kz/index.php/main/article/view/345

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Статьи