Meta-Analysis of the association of FCER1B, FCER2, and ADAM33 gene polymorphisms with asthma

Abstract

Asthma is a complex heterogeneous disease, the development of which is determined by the complex interaction of many predisposition genes and environmental factors. Many epidemiological studies have shown that single nucleotide polymorphism (SNP) in the FCER1B (rs1441586), FCER2 (28364072), and ADAM33 (rs528557) genes are associated with the risk development of asthma. However, the results are inconsistent and inconclusive. The aim of this study was to determine whether the FCER1B (rs1441586), FCER2 (28364072), and ADAM33 (rs528557) polymorphisms confer susceptibility to asthma.  To derive a more precise estimation, a meta-analysis was performed. Meta-analysis was conducted with the data from case-control association studies (20 studies with 9954 controls and 8261 cases). Comprehensive Meta-Analysis software was used for statistical analysis. A random-effects model was used to calculate summary odds ratios (ORs). The meta-analysis showed no association between asthma and the FCER1B rs1441586 variant under any genetic model. A noticeable association of FCER2 (rs28364072) polymorphism with susceptibility to asthma in overall pooled subjects was observed under dominant, recessive, and allele contrast models. Moreover, statistically significant results were obtained for the ADAM33 polymorphism in the allele contrast model. This meta-analysis illustrates that the FCER2 (rs28364072) and ADAM33 (rs528557) polymorphisms may increase susceptibility to asthma.