TP53 gene mutations as a promising marker for radon-induced lung cancerr

Abstract

Lung cancer is the leading cause of death. It is known that in most cases, lung cancer has a multifactorial origins.   Genetic and epigenetic alterations in the cell and the impact damaging environmental factors play an important role in the   pathogenesis of lung cancer. Kazakhstan is the largest producer and exporter of uranium, which is why there is a high level of   contamination with its decay product - radon. The World Health Organization has identified radon as the second factor, after   cigarette smoking is leading to the development of lung cancer. The TP53 gene, known as the" guardian of the genome" is   the most frequent target for mutagen exposure. It is known that mutations in TP53 occur in almost all tumors, including lung   cancer. This article discusses various mutant forms of p53, the etiology of which is based on environmental factors, including   radon.