The role of nuclear factor kappa B (NF-kB) in the pathogenesis of lung cancer

Abstract

Lung cancer is a leader in the mortality rate of malignant neoplasias around the world. The development and
progression of a malignant tumor depends on the balance between cell survival and cell death signals. The main signal for cell
survival is the nuclear factor kappa B (NF-kB), which plays a key role in carcinogenesis and resistance of cancer cells to chemo
and radiotherapy. Recent studies have demonstrated a link between the activation of the NF-kB signaling pathway and the
development of lung cancer. This review highlights the current understanding of the functional features of the NF-kB signaling
pathway and its role in the pathogenesis of lung cancer.