Ultrastructural features of protein-synthetic and energy compartments of hepatocytes in the dynamics of distant tumor growth

Abstract

The article presents the results of the ultrastructural organization of animal hepatocytes under the conditions of   peripheral tumor growth modeling. Hepatocarcinoma-29 was taken as a model of tumor growth, the cells of which were grafted   into the thigh muscle tissue in CBA mice. The ultrastructure of hepatocytes was evaluated by light and electron microscopy   under normal and distant tumor growth conditions after 3, 7, 13, and 30 days of the experiment. It has shown that by the   30th day of tumor development in the hepatocytes, structural signs develop, indicating a violation of the protein-synthetic and   energy function of cells. There is a decrease in bulk density of the cisterns of the granular endoplasmic reticulum, mitochondria   and the numerical density of attached and free polysomal ribosomes. The obtained results indicate the developing insufficiency   of the secretory function of the liver under conditions of peripheral tumor growth.