Structure of the pathways of lymphatic drainage in the liver in conditions of remote tumor growth

Abstract

The liver is the central organ of detoxification and metabolism and is most susceptible to the toxic effects of
products of malignant growth. Therefore, the effectiveness of lymphatic drainage of the organ plays an important role in
maintaining homeostasis of the whole organism. The aim of the study was to identify structural changes in the lymphatic
drainage of the liver during the development of experimental hepatocacinoma-29 in the muscle tissue of the thigh of CBA mice.
Using light, electron microscopy and immunohistochemistry, we studied the structure of various parts of the lymphatic drainage
of the liver under conditions of the development of hepatocarcinoma-29 in the muscular tissue of the thigh of CBA animals. It
was revealed that under conditions of distant tumor growth, structural changes develop in the liver: a decrease in the volume
and numerical density of hepatocytes, an increase in the volume density of sinusoidal spaces, an increase in the size of liver
prelimfatiks — Dissa spaces, an increase in the sinusoidal endothelial cells, an increase in the lumens of the lymph vessels of the
portal tracts. The observed structural changes in various parts of the lymphatic drainage of the liver under conditions of remote
tumor growth indicate an increase in lymphatic processes associated with the presence of toxic metabolites in the blood.